Hyperfunction of pituitary gland

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_HYPERPIT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 965 738 227
Unadjusted prevalence (%) 0.37 0.50 0.20
Mean age at first event (years) 37.98 35.76 45.18

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.88 [1.87, 8.04] 2.8e-4 47
15 years 0.03 4.03 [2.16, 7.51] 1.2e-5 34
5 years 0.01 6.82 [3.62, 12.85] 2.9e-9 15
1 year - - - -

Correlations

Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: 0

Survival analyses between endpoints

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before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland