Hyperfunction of pituitary gland

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_HYPERPIT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 965 738 227
Unadjusted prevalence (%) 0.37 0.50 0.20
Mean age at first event (years) 37.98 35.76 45.18


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.88 [1.87, 8.04] 2.8e-4 47
15 years 0.03 4.03 [2.16, 7.51] 1.2e-5 34
5 years 0.01 6.82 [3.62, 12.85] 2.9e-9 15
1 year - - - -


Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: 0

Survival analyses between endpoints


before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland