Cystic fibrosis with intestinal manifestations

obsolete_cystic fibrosis: ['A congenital metabolic disorder affecting the exocrine glands, inherited as an autosomal trait. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production which causes obstruction of passageways (including pancreatic and bile ducts, intestines, and bronchi). The sweat sodium and chloride content are increased. Symptoms usually appear in childhood and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather. -- 2003', 'A congenital metabolic disorder affecting the exocrine glands, inherited as an autosomal trait. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production which causes obstruction of passageways (including pancreatic and bile ducts, intestines, and bronchi). The sweat sodium and chloride content are increased. Symptoms usually appear in childhood and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather.']

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E84.1
Cause of death: ICD-10 E84.1
KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 E84

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_CYSTFIBRO_INT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E84
Name in latin Fibrosis cystica cum manifestationibus intestinalibus

Summary Statistics

Key figures

All Female Male
Number of individuals 23 11 12
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 25.28 26.45 24.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: E4_CYSTFIBRO_INT – Cystic fibrosis with intestinal manifestations
GWS hits:

Survival analyses between endpoints

Plot

before Cystic fibrosis with intestinal manifestations
after Cystic fibrosis with intestinal manifestations

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Drugs most likely to be purchased after Cystic fibrosis with intestinal manifestations