Metabolic disorders

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E70-E90
Cause of death: ICD-10 E70-E90

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 28946 14238 14708
Unadjusted prevalence (%) 11.13 9.69 13.01
Mean age at first event (years) 61.37 60.96 61.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.98 [3.56, 4.46] <1e-100 4402
15 years 0.03 4.32 [3.87, 4.82] <1e-100 4208
5 years 0.01 7.72 [7.04, 8.47] <1e-100 2548
1 year 0.00 17.18 [15.08, 19.58] <1e-100 1136

Correlations

Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 21

Survival analyses between endpoints

Plot

before Metabolic disorders
after Metabolic disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Metabolic disorders