obsolete_porphyria: ['A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.']
Check pre-conditions None
Include endpoints
Check conditions None
Apply sex-specific rule None
E4_PORBILIR
Extra metadata
List of similar endpoints to
Disorders of porphyrin and bilirubin metabolism
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 180 | 75 | 105 |
| Unadjusted prevalence (%) | 0.07 | 0.05 | 0.09 |
| Mean age at first event (years) | 44.16 | 44.33 | 44.04 |
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | 0.02 | 1.14 [0.45, 2.92] | 7.8e-1 | 12 |
| 15 years | - | - | - | - |
| 5 years | - | - | - | - |
| 1 year | - | - | - | - |
Index endpoint: E4_PORBILIR – Disorders of porphyrin and bilirubin metabolism
GWS hits: 2
before Disorders of porphyrin and bilirubin metabolism
after Disorders of porphyrin and bilirubin metabolism
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