Disorders of iron metabolism

DOID EFO MESH PheWeb

hereditary hemochromatosis type 1: Hemochromatosis type 1 (classic) is the most common form of hereditary hemochromatosis (HH), a group of diseases characterized by excessive tissue iron deposition. Due to its incidence (1/200-1/1000), it is not considered as a rare disease, unlike the other subforms of the disease

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E83.1

Hospital discharge: ICD-9 2750

Cause of death: ICD-10 E83.1

Cause of death: ICD-9 2750

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

E4_IRON_MET

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E83

Name in latin Perturbationes metabolismi ferri

Similar endpoints

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List of similar endpoints to Disorders of iron metabolism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	171	73	98
Unadjusted prevalence (%)	0.07	0.05	0.09
Mean age at first event (years)	55.72	56.31	55.27

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

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Index endpoint: E4_IRON_MET – Disorders of iron metabolism
GWS hits: 5

Survival analyses between endpoints

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Plot

before Disorders of iron metabolism
after Disorders of iron metabolism

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Table

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Drugs most likely to be purchased after Disorders of iron metabolism

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