obsolete_alpha-1-antitrypsin deficiency: ['A lung disease that is characterized as a genetic disorder caused by defective production of alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. Alpha-1 antitrypsin works to protect the lungs from a naturally occuring destructive enzyme that is produced by the lungs in response to infections and toxins (such as cigarette smoke). Without enough A1AT, these enzymes slowly destroy the lung tissue causing emphysema. The symptoms include shortness of breath, wheezing, rhonchi, and rales.']
Filter registries Inpat., Oupat., Death
Check pre-conditions None
Include endpoints None
Check conditions None
Apply sex-specific rule None
E4_PLASMAPROT
Extra metadata
List of similar endpoints to
Disorders of plasma-protein metabolism, not elsewhere classified
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 58 | 41 |
| Unadjusted prevalence (%) | 0.04 | 0.04 | 0.04 |
| Mean age at first event (years) | 50.53 | 48.59 | 53.29 |
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | - | - | - | - |
| 15 years | - | - | - | - |
| 5 years | - | - | - | - |
| 1 year | - | - | - | - |
Index endpoint: E4_PLASMAPROT – Disorders of plasma-protein metabolism, not elsewhere classified
GWS hits: 7
before Disorders of plasma-protein metabolism, not elsewhere classified
after Disorders of plasma-protein metabolism, not elsewhere classified
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