Thyrotoxicosis with diffuse goitre

Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E05.0
Hospital discharge: ICD-9 2420
Hospital discharge: ICD-8 2420
Cause of death: ICD-10 E05.0
Cause of death: ICD-9 2420
Cause of death: ICD-8 2420

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_THYTOXGOITDIF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma diffusa

Summary Statistics

Key figures

All Female Male
Number of individuals 2777 2305 472
Unadjusted prevalence (%) 1.07 1.57 0.42
Mean age at first event (years) 48.50 47.83 51.74


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.84 [1.26, 2.67] 1.4e-3 116
15 years 0.01 1.95 [1.31, 2.91] 1.1e-3 94
5 years 0.00 2.68 [1.69, 4.24] 2.7e-5 36
1 year 0.00 5.32 [2.84, 9.96] 1.8e-7 13


Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 10

Survival analyses between endpoints


before Thyrotoxicosis with diffuse goitre
after Thyrotoxicosis with diffuse goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Thyrotoxicosis with diffuse goitre