Disorders of the thyroid gland

thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

Endpoint definition

FinnGen phenotype data
diagram downward connector E4_THYROID

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 38425 30609 7816
Unadjusted prevalence (%) 14.78 20.83 6.91
Mean age at first event (years) 51.41 49.93 57.19


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.58 [1.39, 1.79] 2.1e-12 2610
15 years 0.01 1.74 [1.55, 1.95] 1.5e-21 2048
5 years 0.00 2.42 [2.15, 2.72] 1.9e-49 747
1 year 0.00 2.37 [1.92, 2.92] 7.8e-16 135


Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 58

Survival analyses between endpoints


before Disorders of the thyroid gland
after Disorders of the thyroid gland

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of the thyroid gland