Hypothyroidism, other/unspecified

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5
Hospital discharge: ICD-9 244[8-9]
Hospital discharge: ICD-8 244
Hospital discharge: excluded ICD-9 2448A|2448B
Hospital discharge: excluded ICD-8 24409
Cause of death: ICD-9 244[8-9]
Cause of death: ICD-8 244
Cause of death: excluded ICD-9 2448A|2448B
KELA reimbursements: KELA codes 104
KELA reimbursements: ICD-10 E03
Medicine purchases: ATC H03A
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_HYTHYNAS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Hypothyroidism, other/unspecified based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 32866 26327 6539
Unadjusted prevalence (%) 12.64 17.92 5.78
Mean age at first event (years) 52.20 50.81 57.81


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.50 [1.32, 1.69] 1.5e-10 2129
15 years 0.01 1.70 [1.53, 1.90] 2.9e-21 1699
5 years 0.00 2.37 [2.10, 2.67] 4.9e-45 615
1 year 0.00 1.91 [1.50, 2.43] 1.4e-7 90


Index endpoint: E4_HYTHYNAS – Hypothyroidism, other/unspecified
GWS hits: 87

Survival analyses between endpoints


before Hypothyroidism, other/unspecified
after Hypothyroidism, other/unspecified

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Drugs most likely to be purchased after Hypothyroidism, other/unspecified