Hypothyroidism, other/unspecified

DOID EFO MESH SNOMED PheWeb

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5

Hospital discharge: ICD-9 244[8-9]

Hospital discharge: ICD-8 244

Hospital discharge: excluded ICD-9 2448A|2448B

Hospital discharge: excluded ICD-8 24409

Cause of death: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5

Cause of death: ICD-9 244[8-9]

Cause of death: ICD-8 244

Cause of death: excluded ICD-9 2448A|2448B

KELA reimbursements: KELA codes 104

KELA reimbursements: ICD-10 E03

Medicine purchases: ATC H03A

Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

E4_HYTHYNAS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Hypothyroidism, other/unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	32866	26327	6539
Unadjusted prevalence (%)	12.64	17.92	5.78
Mean age at first event (years)	52.20	50.81	57.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.50 [1.32, 1.69]	1.5e-10	2129
15 years	0.01	1.70 [1.53, 1.90]	2.9e-21	1699
5 years	0.00	2.37 [2.10, 2.67]	4.9e-45	615
1 year	0.00	1.91 [1.50, 2.43]	1.4e-7	90

Correlations

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Index endpoint: E4_HYTHYNAS – Hypothyroidism, other/unspecified
GWS hits: 87

Survival analyses between endpoints

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Plot

before Hypothyroidism, other/unspecified
after Hypothyroidism, other/unspecified

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Table

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Drugs most likely to be purchased after Hypothyroidism, other/unspecified

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