Hypothyroidism and >3 levothyroxin purchases

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

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Check conditions

HYPOTHYROIDISM

Apply sex-specific rule None

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Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Hypothyroidism and >3 levothyroxin purchases based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 32576 26120 6456
Unadjusted prevalence (%) 12.53 17.77 5.71
Mean age at first event (years) 52.32 50.94 57.89

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.41 [1.23, 1.62] 1.1e-6 2083
15 years 0.01 1.62 [1.44, 1.82] 2.5e-15 1658
5 years 0.00 2.25 [1.99, 2.55] 9.4e-38 577
1 year 0.00 1.51 [1.16, 1.97] 2.3e-3 70

Correlations

Index endpoint: HYPOTHY_PURCHASE – Hypothyroidism and >3 levothyroxin purchases
GWS hits: 37

Survival analyses between endpoints

Plot

before Hypothyroidism and >3 levothyroxin purchases
after Hypothyroidism and >3 levothyroxin purchases

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Drugs most likely to be purchased after Hypothyroidism and >3 levothyroxin purchases