Thyrotoxicosis, other and/or unspecified

DOID EFO MESH SNOMED PheWeb

Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E05[4-9]

Hospital discharge: ICD-9 2423

Hospital discharge: ICD-8 2422

Cause of death: ICD-10 E05[4-9]

Cause of death: ICD-9 2423

Cause of death: ICD-8 2422

Medicine purchases: ATC H03B

Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

E4_THYTOXNAS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Thyrotoxicosis, other and/or unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3961	3143	818
Unadjusted prevalence (%)	1.52	2.14	0.72
Mean age at first event (years)	52.24	51.09	56.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.14 [2.22, 4.44]	1.1e-10	224
15 years	0.03	3.57 [2.68, 4.75]	2.4e-18	198
5 years	0.01	4.85 [3.58, 6.56]	1.4e-24	96
1 year	0.00	5.89 [3.44, 10.08]	1.0e-10	26

Correlations

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Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified
GWS hits: 13

Survival analyses between endpoints

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Plot

before Thyrotoxicosis, other and/or unspecified
after Thyrotoxicosis, other and/or unspecified

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Table

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Drugs most likely to be purchased after Thyrotoxicosis, other and/or unspecified

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