Thyrotoxicosis, other and/or unspecified

Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E05[4-9]
Hospital discharge: ICD-9 2423
Hospital discharge: ICD-8 2422
Cause of death: ICD-10 E05[4-9]
Cause of death: ICD-9 2423
Cause of death: ICD-8 2422
Medicine purchases: ATC H03B
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_THYTOXNAS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 3961 3143 818
Unadjusted prevalence (%) 1.52 2.14 0.72
Mean age at first event (years) 52.24 51.09 56.64


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.14 [2.22, 4.44] 1.1e-10 224
15 years 0.03 3.57 [2.68, 4.75] 2.4e-18 198
5 years 0.01 4.85 [3.58, 6.56] 1.4e-24 96
1 year 0.00 5.89 [3.44, 10.08] 1.0e-10 26


Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified
GWS hits: 13

Survival analyses between endpoints


before Thyrotoxicosis, other and/or unspecified
after Thyrotoxicosis, other and/or unspecified

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Thyrotoxicosis, other and/or unspecified