Dementia in Alzheimer disease

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F00*
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*
Cause of death: ICD-8 29010

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_ALZHDEMENT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 2574 1317 1257
Unadjusted prevalence (%) 0.99 0.90 1.11
Mean age at first event (years) 79.32 79.91 78.69


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.18 12.64 [10.95, 14.60] <1e-100 1551
15 years 0.09 12.61 [10.91, 14.56] <1e-100 1544
5 years 0.02 13.71 [12.03, 15.61] <1e-100 1168
1 year 0.00 16.85 [14.26, 19.92] <1e-100 392


Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 2

Survival analyses between endpoints


before Dementia in Alzheimer disease
after Dementia in Alzheimer disease

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Drugs most likely to be purchased after Dementia in Alzheimer disease