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Dementia

DOIDEFOMESH PheWeb

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

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FinnGen phenotype data
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Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 F00-F09
Hospital discharge: ICD-9 290|3310|4378A
Hospital discharge: ICD-8 290
Cause of death: ICD-10 F00-F09
Cause of death: ICD-9 290|3310|4378A
Cause of death: ICD-8 290
KELA reimbursements: KELA codes 307
Medicine purchases: ATC N06D
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

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Include endpoints

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 9245 4464 4781
Unadjusted prevalence (%) 3.56 3.04 4.23
Mean age at first event (years) 76.79 77.41 76.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.18 11.75 [10.61, 13.01] <1e-100 4165
15 years 0.10 11.72 [10.58, 12.99] <1e-100 4137
5 years 0.02 12.07 [10.95, 13.31] <1e-100 2893
1 year 0.00 13.71 [11.95, 15.73] <1e-100 918

Correlations

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Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 3

Survival analyses between endpoints

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Plot

before Dementia
after Dementia

loading spinner Loading survival analyses plot