Mental retardation

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F70-F79
Cause of death: ICD-10 F70-F79

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_MENTRET

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 827 403 424
Unadjusted prevalence (%) 0.32 0.27 0.37
Mean age at first event (years) 27.02 27.47 26.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.81 [3.46, 9.77] 2.9e-11 84
15 years 0.04 6.37 [4.00, 10.14] 6.4e-15 59
5 years 0.01 9.17 [4.94, 17.04] 2.2e-12 21
1 year - - - -

Correlations

Index endpoint: F5_MENTRET – Mental retardation
GWS hits: 1

Survival analyses between endpoints

Plot

before Mental retardation
after Mental retardation

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Drugs most likely to be purchased after Mental retardation