MS-disease / Multiple Sclerosis

DOID EFO MESH SNOMED PheWeb

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 G35

Hospital discharge: ICD-9 340

Hospital discharge: ICD-8 34099

Cause of death: ICD-10 G35

Cause of death: ICD-9 340

Cause of death: ICD-8 34099

KELA reimbursements: KELA codes 109

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

G6_MS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G35-G37

Name in latin Sclerosis multiplex

Similar endpoints

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List of similar endpoints to MS-disease / Multiple Sclerosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1363	1045	318
Unadjusted prevalence (%)	0.52	0.71	0.28
Mean age at first event (years)	39.39	38.44	42.51

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.09 [1.78, 5.37]	6.4e-5	57
15 years	0.02	3.45 [2.02, 5.90]	6.3e-6	46
5 years	0.01	4.72 [2.64, 8.45]	1.8e-7	17
1 year	-	-	-	-

Correlations

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 1

Survival analyses between endpoints

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Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after MS-disease / Multiple Sclerosis

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