Sensorineural hearing loss

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H8_HL_SEN_NAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 19313 9324 9989
Unadjusted prevalence (%) 7.43 6.34 8.83
Mean age at first event (years) 63.37 61.88 64.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.81 [1.55, 2.11] 2.5e-14 2303
15 years 0.01 1.99 [1.74, 2.29] 7.1e-23 2123
5 years 0.00 2.68 [2.38, 3.02] 1.3e-57 991
1 year 0.00 2.63 [2.17, 3.20] 1.0e-22 189

Correlations

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Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 12

Survival analyses between endpoints

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Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss

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