Sensorineural hearing loss

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H8_HL_SEN_NAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 19313 9324 9989
Unadjusted prevalence (%) 7.43 6.34 8.83
Mean age at first event (years) 63.37 61.88 64.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.81 [1.55, 2.11] 2.5e-14 2303
15 years 0.01 1.99 [1.74, 2.29] 7.1e-23 2123
5 years 0.00 2.68 [2.38, 3.02] 1.3e-57 991
1 year 0.00 2.63 [2.17, 3.20] 1.0e-22 189

Correlations

Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 12

Survival analyses between endpoints

Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss