Coronary atherosclerosis

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1
Hospital discharge: ICD-9 414|9960A
Hospital discharge: ICD-8 414
Hospital discharge: excluded ICD-10 I25.3
Cause of death: ICD-10 I24, I25, T82.2, Z95.1
Cause of death: ICD-9 414|9960A
Cause of death: ICD-8 414
Cause of death: excluded ICD-10 I25.3

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector I9_CORATHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 28573 9247 19326
Unadjusted prevalence (%) 10.99 6.29 17.09
Mean age at first event (years) 66.42 68.06 65.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.93 [4.46, 5.45] <1e-100 9003
15 years 0.04 5.95 [5.47, 6.48] <1e-100 8382
5 years 0.01 10.75 [9.90, 11.67] <1e-100 5002
1 year 0.01 29.05 [25.50, 33.09] <1e-100 2875

Correlations

Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 52

Survival analyses between endpoints

Plot

before Coronary atherosclerosis
after Coronary atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Coronary atherosclerosis