myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ ]

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 I40, I41*
Hospital discharge: ICD-9 422
Hospital discharge: ICD-8 0742|422
Cause of death: ICD-10 I40, I41*
Cause of death: ICD-9 422
Cause of death: ICD-8 0742|422

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector I9_MYOCARD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 987 387 600
Unadjusted prevalence (%) 0.38 0.26 0.53
Mean age at first event (years) 43.15 46.78 40.82


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 6.36 [3.97, 10.17] 1.2e-14 106
15 years 0.05 7.34 [4.95, 10.88] 2.8e-23 89
5 years 0.01 13.48 [9.14, 19.88] 2.6e-39 53
1 year - - - -


Index endpoint: I9_MYOCARD – Myocarditis
GWS hits: 1

Survival analyses between endpoints


before Myocarditis
after Myocarditis

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