Rheumatic fever without mention of heart involvement

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Hospital discharge: ICD-9 390
Hospital discharge: ICD-8 390
Cause of death: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Cause of death: ICD-9 390
Cause of death: ICD-8 390

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector I9_RHEUFEVWITHOUTHEART

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 70 33 37
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 32.32 29.47 34.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits:

Survival analyses between endpoints

Plot

before Rheumatic fever without mention of heart involvement
after Rheumatic fever without mention of heart involvement

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Drugs most likely to be purchased after Rheumatic fever without mention of heart involvement