Gastro-oesophageal reflux disease

gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K21
Hospital discharge: ICD-9 5301A
Cause of death: ICD-10 K21
Cause of death: ICD-9 5301A

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector K11_REFLUX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Morbus refluxualis gastro-oesophageus

Summary Statistics

Key figures

All Female Male
Number of individuals 16042 9273 6769
Unadjusted prevalence (%) 6.17 6.31 5.99
Mean age at first event (years) 54.26 53.59 55.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.92 [1.61, 2.30] 1.1e-12 1243
15 years 0.02 2.21 [1.87, 2.61] 1.4e-20 1060
5 years 0.00 3.71 [3.16, 4.36] 1.7e-57 483
1 year 0.00 5.32 [4.23, 6.69] 3.3e-46 130

Correlations

Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits: 1

Survival analyses between endpoints

Plot

before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Gastro-oesophageal reflux disease