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Atopic dermatitis

DOIDEFOMESH PheWeb

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 L20
Hospital discharge: ICD-9 6918
Hospital discharge: ICD-8 691
Hospital discharge: excluded ICD-9 6918X
Cause of death: ICD-10 L20
Cause of death: ICD-9 6918
Cause of death: ICD-8 691
Cause of death: excluded ICD-9 6918X
KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 L20

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector L12_ATOPIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L20-L30
Name in latin Dermatitis atopica

Summary Statistics

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Key figures

All Female Male
Number of individuals 8383 5863 2520
Unadjusted prevalence (%) 3.22 3.99 2.23
Mean age at first event (years) 29.96 30.25 29.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.99 [1.48, 2.67] 5.3e-6 198
15 years 0.01 2.01 [1.43, 2.82] 6.2e-5 151
5 years 0.00 3.19 [2.18, 4.67] 2.1e-9 62
1 year 0.00 4.26 [2.39, 7.59] 9.3e-7 15

Correlations

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Index endpoint: L12_ATOPIC – Atopic dermatitis
GWS hits: 31

Survival analyses between endpoints

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Plot

before Atopic dermatitis
after Atopic dermatitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atopic dermatitis

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