Coxarthrosis,

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M16
Hospital discharge: ICD-9 7151E|7152E
Hospital discharge: ICD-8 71300
Cause of death: ICD-10 M16
Cause of death: ICD-9 7151E|7152E
Cause of death: ICD-8 71300

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_ARTHTROSIS_COX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Coxarthrosis

Summary Statistics

Key figures

All Female Male
Number of individuals 13115 7142 5973
Unadjusted prevalence (%) 5.04 4.86 5.28
Mean age at first event (years) 63.31 63.34 63.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.70 [1.43, 2.01] 9.9e-10 1568
15 years 0.01 1.72 [1.45, 2.03] 2.3e-10 1308
5 years 0.00 2.13 [1.83, 2.47] 3.4e-23 468
1 year 0.00 2.02 [1.56, 2.61] 9.2e-8 83

Correlations

Index endpoint: M13_ARTHTROSIS_COX – Coxarthrosis,
GWS hits: 14

Survival analyses between endpoints

Plot

before Coxarthrosis,
after Coxarthrosis,

loading spinner Loading survival analyses plot