Osteoporosis

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M80, M81, M82*
Hospital discharge: ICD-9 733[0-1]
Hospital discharge: ICD-8 7230|72391
Cause of death: ICD-10 M80, M81, M82*
Cause of death: ICD-9 733[0-1]
Cause of death: ICD-8 7230|72391

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_OSTEOPOROSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Osteoporosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 3959 3076 883
Unadjusted prevalence (%) 1.52 2.09 0.78
Mean age at first event (years) 65.28 66.24 61.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 6.08 [4.39, 8.41] 1.2e-27 768
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Osteoporosis
after Osteoporosis

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