Macular hole

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector MACULAR_HOLE

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

Key figures

All Female Male
Number of individuals 659 395 264
Unadjusted prevalence (%) 0.25 0.27 0.23
Mean age at first event (years) 69.94 68.26 72.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.51 [1.93, 6.40] 4.1e-5 34
15 years 0.02 3.51 [1.93, 6.40] 4.1e-5 34
5 years 0.00 3.98 [2.17, 7.30] 8.0e-6 28
1 year - - - -

Correlations

Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 0

Survival analyses between endpoints

Plot

before Macular hole
after Macular hole

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