Macular hole

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector MACULAR_HOLE

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

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Key figures

All Female Male
Number of individuals 659 395 264
Unadjusted prevalence (%) 0.25 0.27 0.23
Mean age at first event (years) 69.94 68.26 72.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.51 [1.93, 6.40] 4.1e-5 34
15 years 0.02 3.51 [1.93, 6.40] 4.1e-5 34
5 years 0.00 3.98 [2.17, 7.30] 8.0e-6 28
1 year - - - -

Correlations

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Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 0

Survival analyses between endpoints

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Plot

before Macular hole
after Macular hole

loading spinner Loading survival analyses plot