Seropositive rheumatoid arthritis, wide

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector RHEUMA_SEROPOS_WIDE

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 5855 4124 1731
Unadjusted prevalence (%) 2.25 2.81 1.53
Mean age at first event (years) 53.86 52.58 56.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.27 [1.81, 2.86] 2.9e-12 699
15 years 0.02 2.51 [2.06, 3.06] 1.2e-19 544
5 years 0.00 3.15 [2.59, 3.84] 5.5e-30 187
1 year 0.00 2.76 [1.87, 4.08] 3.2e-7 31

Correlations

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Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 24

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide

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