Seropositive rheumatoid arthritis, strict definition

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

Endpoint definition

FinnGen phenotype data
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Filter registries KELA purch., KELA reimb.

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M05.8, M05.9

Check pre-conditions None

Include endpoints None

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Check conditions

RHEUMA_SEROPOS_OTH_ICD10

Apply sex-specific rule None

diagram downward connector RHEUMA_SEROPOS_STRICT

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1580 1123 457
Unadjusted prevalence (%) 0.61 0.76 0.40
Mean age at first event (years) 57.34 56.00 60.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.41 [1.10, 5.25] 2.7e-2 43
15 years 0.02 2.42 [1.08, 5.45] 3.3e-2 37
5 years 0.00 3.71 [1.79, 7.71] 4.4e-4 22
1 year - - - -

Correlations

Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition
GWS hits: 8

Survival analyses between endpoints

Plot

before Seropositive rheumatoid arthritis, strict definition
after Seropositive rheumatoid arthritis, strict definition

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, strict definition