Seropositive rheumatoid arthritis, wide

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector RHEUMA_SEROPOS_WIDE

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

Key figures

All Female Male
Number of individuals 5855 4124 1731
Unadjusted prevalence (%) 2.25 2.81 1.53
Mean age at first event (years) 53.86 52.58 56.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.27 [1.81, 2.86] 2.9e-12 699
15 years 0.02 2.51 [2.06, 3.06] 1.2e-19 544
5 years 0.00 3.15 [2.59, 3.84] 5.5e-30 187
1 year 0.00 2.76 [1.87, 4.08] 3.2e-7 31

Correlations

Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 24

Survival analyses between endpoints

Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide