Endpoint definition
↥
FinnGen phenotype data
Filter registries None
Check pre-conditions None
Check conditions None
Apply sex-specific rule None
RHEUMA_SEROPOS
Extra metadata
First used in FinnGen datafreeze
DF2
Seropositive rheumatoid arthritis
rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
RHEUMA_SEROPOS
Similar endpoints
↥List of similar endpoints to
Seropositive rheumatoid arthritis
based on the number of shared cases.
Broader endpoints:
- Polyarthropathies
- Immune disease comorbidities
- Immune disease comorbidities
- Autoimmune diseases
- Finngen Rheumatological endpoints
Narrower endpoints:
Summary Statistics
↥Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5857 | 4124 | 1733 |
| Unadjusted prevalence (%) | 2.25 | 2.81 | 1.53 |
| Mean age at first event (years) | 53.86 | 52.58 | 56.89 |
Mortality
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | 0.04 | 2.57 [2.04, 3.24] | 8.9e-16 | 700 |
| 15 years | 0.02 | 2.82 [2.34, 3.41] | 1.4e-27 | 544 |
| 5 years | 0.00 | 3.40 [2.81, 4.12] | 3.0e-36 | 187 |
| 1 year | 0.00 | 2.99 [2.03, 4.40] | 2.6e-8 | 31 |
Correlations
↥
Index endpoint: RHEUMA_SEROPOS – Seropositive rheumatoid arthritis
GWS hits: 29
Survival analyses between endpoints
↥Plot
before Seropositive rheumatoid arthritis
after Seropositive rheumatoid arthritis
Loading survival analyses plot
Table
Loading survival analyses table