Rheumatoid arthritis

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_RHEUMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 7909 5481 2428
Unadjusted prevalence (%) 3.04 3.73 2.15
Mean age at first event (years) 51.33 50.01 54.31

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.67 [1.33, 2.10] 9.4e-6 897
15 years 0.01 1.91 [1.57, 2.32] 5.6e-11 686
5 years 0.00 2.60 [2.15, 3.15] 1.8e-22 246
1 year 0.00 2.78 [2.00, 3.86] 1.1e-9 48

Correlations

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Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 19

Survival analyses between endpoints

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Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatoid arthritis

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