Rheumatoid arthritis

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_RHEUMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 7909 5481 2428
Unadjusted prevalence (%) 3.04 3.73 2.15
Mean age at first event (years) 51.33 50.01 54.31


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.67 [1.33, 2.10] 9.4e-6 897
15 years 0.01 1.91 [1.57, 2.32] 5.6e-11 686
5 years 0.00 2.60 [2.15, 3.15] 1.8e-22 246
1 year 0.00 2.78 [2.00, 3.86] 1.1e-9 48


Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 19

Survival analyses between endpoints


before Rheumatoid arthritis
after Rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatoid arthritis