Seronegative rheumatoid arthritis

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector RHEUMA_SERONEG

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

Key figures

All Female Male
Number of individuals 2484 1784 700
Unadjusted prevalence (%) 0.96 1.21 0.62
Mean age at first event (years) 53.01 51.82 56.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.12 [1.52, 2.96] 8.3e-6 204
15 years 0.01 2.22 [1.65, 2.98] 1.3e-7 156
5 years 0.00 2.92 [2.08, 4.09] 4.8e-10 53
1 year 0.00 3.70 [2.01, 6.81] 2.6e-5 12

Correlations

Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 2

Survival analyses between endpoints

Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seronegative rheumatoid arthritis