Seronegative rheumatoid arthritis

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector RHEUMA_SERONEG

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

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Key figures

All Female Male
Number of individuals 2484 1784 700
Unadjusted prevalence (%) 0.96 1.21 0.62
Mean age at first event (years) 53.01 51.82 56.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.12 [1.52, 2.96] 8.3e-6 204
15 years 0.01 2.22 [1.65, 2.98] 1.3e-7 156
5 years 0.00 2.92 [2.08, 4.09] 4.8e-10 53
1 year 0.00 3.70 [2.01, 6.81] 2.6e-5 12

Correlations

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Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seronegative rheumatoid arthritis

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