Adult-onset Still disease

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M06.1
Cause of death: ICD-10 M06.1

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector STILL_ADULT

Extra metadata

First used in FinnGen datafreeze DF5
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Similar endpoints

List of similar endpoints to Adult-onset Still disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 4336 3042 1294
Unadjusted prevalence (%) 1.67 2.07 1.14
Mean age at first event (years) 49.88 48.59 52.91


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.01 [1.53, 2.64] 5.3e-7 534
15 years 0.02 2.42 [1.93, 3.03] 2.0e-14 417
5 years 0.00 3.74 [3.01, 4.64] 1.2e-32 166
1 year 0.00 5.51 [3.93, 7.74] 5.9e-23 46


Index endpoint: STILL_ADULT – Adult-onset Still disease
GWS hits: 4

Survival analyses between endpoints


before Adult-onset Still disease
after Adult-onset Still disease

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Drugs most likely to be purchased after Adult-onset Still disease