Adult-onset Still disease

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M06.1
Cause of death: ICD-10 M06.1

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector STILL_ADULT

Extra metadata

First used in FinnGen datafreeze DF5
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Similar endpoints

List of similar endpoints to Adult-onset Still disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 4336 3042 1294
Unadjusted prevalence (%) 1.67 2.07 1.14
Mean age at first event (years) 49.88 48.59 52.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.01 [1.53, 2.64] 5.3e-7 534
15 years 0.02 2.42 [1.93, 3.03] 2.0e-14 417
5 years 0.00 3.74 [3.01, 4.64] 1.2e-32 166
1 year 0.00 5.51 [3.93, 7.74] 5.9e-23 46

Correlations

Index endpoint: STILL_ADULT – Adult-onset Still disease
GWS hits: 4

Survival analyses between endpoints

Plot

before Adult-onset Still disease
after Adult-onset Still disease

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Drugs most likely to be purchased after Adult-onset Still disease