Non-allergic asthma

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

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Check conditions

not L12_ATOPIC
and not ALLERG_RHINITIS
and not H7_ALLERGICCONJUNCTIVITIS
and not FOOD_ALLERGY
and not Z21_DESEN_ALLERGE
and not POLLENALLERG

Apply sex-specific rule None

diagram downward connector ASTHMA_NONALLERG

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 3752 2143 1609
Unadjusted prevalence (%) 1.44 1.46 1.42
Mean age at first event (years) 51.35 49.67 53.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.08 [1.53, 2.85] 3.8e-6 518
15 years 0.02 2.62 [2.03, 3.38] 1.1e-13 455
5 years 0.00 4.04 [3.19, 5.12] 3.8e-31 175
1 year 0.00 4.74 [3.27, 6.88] 2.5e-16 38

Correlations

Index endpoint: ASTHMA_NONALLERG – Non-allergic asthma
GWS hits: 0

Survival analyses between endpoints

Plot

before Non-allergic asthma
after Non-allergic asthma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-allergic asthma