Non-allergic asthma (mode)

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 (mode) J45.1
Cause of death: ICD-10 (mode) J45.1

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector NONALLERG_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 4430 2635 1795
Unadjusted prevalence (%) 1.70 1.79 1.59
Mean age at first event (years) 49.85 48.47 51.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.24 [1.57, 3.21] 1.0e-5 553
15 years 0.02 2.58 [1.87, 3.55] 6.7e-9 480
5 years 0.00 3.67 [2.73, 4.95] 9.9e-18 182
1 year 0.00 4.26 [2.84, 6.38] 2.0e-12 39

Correlations

Index endpoint: NONALLERG_ASTHMA – Non-allergic asthma (mode)
GWS hits: 1

Survival analyses between endpoints

Plot

before Non-allergic asthma (mode)
after Non-allergic asthma (mode)

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Drugs most likely to be purchased after Non-allergic asthma (mode)