Chron's disease NAS

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K50.9
Cause of death: ICD-10 K50.9

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector CHRONNAS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50
Name in latin Morbus Crohn non specificatus

Summary Statistics

Key figures

All Female Male
Number of individuals 1237 699 538
Unadjusted prevalence (%) 0.48 0.48 0.48
Mean age at first event (years) 44.41 43.29 45.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.22 [2.12, 8.39] 4.1e-5 75
15 years 0.03 4.52 [2.20, 9.29] 4.1e-5 74
5 years 0.01 8.57 [4.82, 15.27] 2.9e-13 48
1 year 0.00 11.02 [5.73, 21.20] 6.6e-13 15

Correlations

Index endpoint: CHRONNAS – Chron's disease NAS
GWS hits: 3

Survival analyses between endpoints

Plot

before Chron's disease NAS
after Chron's disease NAS

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chron's disease NAS