Crohn disease

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector K11_CROHN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 2532 1424 1108
Unadjusted prevalence (%) 0.97 0.97 0.98
Mean age at first event (years) 42.57 41.02 44.56


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.17 [2.03, 4.96] 4.0e-7 133
15 years 0.03 3.90 [2.67, 5.72] 2.7e-12 116
5 years 0.01 7.56 [5.36, 10.65] 7.0e-31 64
1 year 0.00 9.21 [5.42, 15.67] 2.4e-16 17


Index endpoint: K11_CROHN – Crohn disease
GWS hits: 4

Survival analyses between endpoints


before Crohn disease
after Crohn disease

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