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Crohn disease (strict definition, require KELA, min 2 HDR)

DOIDEFOMESHSNOMED PheWeb

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630

Check pre-conditions None

Include endpoints None

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Check conditions

K11_KELACROHN
and K11_CROHN number of events >1

Apply sex-specific rule None

diagram downward connector K11_CD_STRICT2

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Summary Statistics

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Key figures

All Female Male
Number of individuals 1020 597 423
Unadjusted prevalence (%) 0.39 0.41 0.37
Mean age at first event (years) 40.04 40.03 40.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.29 [0.50, 3.33] 6.0e-1 18
15 years 0.01 1.68 [0.73, 3.87] 2.3e-1 14
5 years - - - -
1 year - - - -

Correlations

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Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)
GWS hits: 3

Survival analyses between endpoints

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Plot

before Crohn disease (strict definition, require KELA, min 2 HDR)
after Crohn disease (strict definition, require KELA, min 2 HDR)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Crohn disease (strict definition, require KELA, min 2 HDR)

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