Early onset COPD

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 J44
Hospital discharge: ICD-9 4912
Hospital discharge: ICD-8 49104
Cause of death: ICD-10 J44
Cause of death: ICD-9 4912
Cause of death: ICD-8 49104
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Check pre-conditions

Pre-conditions EVENT_AGE<65

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Summary Statistics

Key figures

All Female Male
Number of individuals 4485 1713 2772
Unadjusted prevalence (%) 1.72 1.17 2.45
Mean age at first event (years) 54.38 52.83 55.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.82 [3.71, 6.27] 4.9e-32 914
15 years 0.04 5.80 [4.71, 7.14] 2.0e-61 788
5 years - - - -
1 year - - - -

Correlations

Index endpoint: COPD_EARLY – Early onset COPD
GWS hits: 3

Survival analyses between endpoints

Plot

before Early onset COPD
after Early onset COPD

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Drugs most likely to be purchased after Early onset COPD