chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

Check conditions None

Apply sex-specific rule None

diagram downward connector J10_COPD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 9558 2915 6643
Unadjusted prevalence (%) 3.68 1.98 5.87
Mean age at first event (years) 63.76 60.20 65.33


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 7.16 [6.30, 8.13] <1e-100 3431
15 years - - - -
5 years - - - -
1 year - - - -


Index endpoint: J10_COPD – COPD
GWS hits: 3

Survival analyses between endpoints


before COPD
after COPD

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