Eosinophilia

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D72.1
Hospital discharge: ICD-9 2883
Cause of death: ICD-10 D72.1
Cause of death: ICD-9 2883

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector D3_EOSINOPHILIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 222 117 105
Unadjusted prevalence (%) 0.09 0.08 0.09
Mean age at first event (years) 53.45 50.82 56.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

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Index endpoint: D3_EOSINOPHILIA – Eosinophilia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Eosinophilia
after Eosinophilia

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