Other disorders of white blood cells

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D72
Cause of death: ICD-10 D72

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector D3_OTHERWHITECELL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Aliae morbositates leucocytorum

Similar endpoints

List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 820 433 387
Unadjusted prevalence (%) 0.32 0.29 0.34
Mean age at first event (years) 53.86 50.71 57.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.60 [2.11, 6.17] 2.9e-6 105
15 years 0.03 4.30 [2.67, 6.95] 2.4e-9 94
5 years 0.01 8.03 [5.01, 12.88] 5.3e-18 57
1 year - - - -

Correlations

Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: 1

Survival analyses between endpoints

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Drugs most likely to be purchased after Other disorders of white blood cells