Endpoint definition
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Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
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List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
All | Female | Male | |
---|---|---|---|
Number of individuals | 820 | 433 | 387 |
Unadjusted prevalence (%) | 0.32 | 0.29 | 0.34 |
Mean age at first event (years) | 53.86 | 50.71 | 57.38 |
Follow-up | Absolute risk | HR [95% CI] | p | N |
---|---|---|---|---|
1998–2019 | 0.05 | 3.60 [2.11, 6.17] | 2.9e-6 | 105 |
15 years | 0.03 | 4.30 [2.67, 6.95] | 2.4e-9 | 94 |
5 years | 0.01 | 8.03 [5.01, 12.88] | 5.3e-18 | 57 |
1 year | - | - | - | - |
Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: 1
before Other disorders of white blood cells
after Other disorders of white blood cells
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