lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.
Filter registries Inpat., Oupat., Death
Check pre-conditions None
Include endpoints None
Check conditions None
Apply sex-specific rule None
E4_LACTONAS
Extra metadata
List of similar endpoints to
Lactose intolerance, other/unspecified
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
None
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 471 | 328 | 143 |
| Unadjusted prevalence (%) | 0.18 | 0.22 | 0.13 |
| Mean age at first event (years) | 38.02 | 37.88 | 38.33 |
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | 0.03 | 2.17 [0.96, 4.91] | 6.4e-2 | 39 |
| 15 years | 0.02 | 3.08 [1.59, 5.94] | 8.1e-4 | 35 |
| 5 years | 0.00 | 3.82 [2.05, 7.11] | 2.5e-5 | 13 |
| 1 year | - | - | - | - |
Index endpoint: E4_LACTONAS – Lactose intolerance, other/unspecified
GWS hits: 2
before Lactose intolerance, other/unspecified
after Lactose intolerance, other/unspecified
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