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Schizophrenia

DOIDEFOMESHSNOMED PheWeb

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F20
Hospital discharge: ICD-9 295
Hospital discharge: ICD-8 295
Hospital discharge: excluded ICD-9 2954|2957
Hospital discharge: excluded ICD-8 2957
Cause of death: ICD-10 F20
Cause of death: ICD-9 295
Cause of death: ICD-8 295
Cause of death: excluded ICD-9 2954|2957
Cause of death: excluded ICD-8 2957

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_SCHZPHR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Summary Statistics

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Key figures

All Female Male
Number of individuals 5758 2579 3179
Unadjusted prevalence (%) 2.21 1.75 2.81
Mean age at first event (years) 31.67 32.88 30.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.25 [2.53, 4.17] 2.6e-20 372
15 years 0.02 2.96 [2.32, 3.77] 1.5e-18 198
5 years 0.00 4.17 [3.11, 5.61] 2.5e-21 60
1 year 0.00 5.05 [2.88, 8.86] 1.6e-8 14

Correlations

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Index endpoint: F5_SCHZPHR – Schizophrenia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Schizophrenia
after Schizophrenia

loading spinner Loading survival analyses plot