Schizophrenia, schizotypal and delusional disorders

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F20
Cause of death: ICD-10 F20

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_SCHIZO

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 10793 5535 5258
Unadjusted prevalence (%) 4.15 3.77 4.65
Mean age at first event (years) 33.74 35.02 32.40

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.92 [2.41, 3.53] 1.5e-28 810
15 years 0.02 3.16 [2.66, 3.76] 2.5e-39 546
5 years 0.00 4.94 [4.13, 5.90] 8.4e-69 216
1 year 0.00 6.95 [5.18, 9.33] 4.7e-38 59

Correlations

Index endpoint: F5_SCHIZO – Schizophrenia, schizotypal and delusional disorders
GWS hits: 1

Survival analyses between endpoints

Plot

before Schizophrenia, schizotypal and delusional disorders
after Schizophrenia, schizotypal and delusional disorders

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Drugs most likely to be purchased after Schizophrenia, schizotypal and delusional disorders