Diabetic maculopathy

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H36.01*
Cause of death: ICD-10 H36.01*

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H7_MACULOPATHYDIAB

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2273 931 1342
Unadjusted prevalence (%) 0.87 0.63 1.19
Mean age at first event (years) 50.75 48.86 52.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 5.36 [3.32, 8.64] 6.3e-12 406
15 years 0.04 6.15 [4.33, 8.72] 2.2e-24 368
5 years 0.01 8.77 [6.78, 11.34] 2.4e-61 168
1 year 0.00 7.59 [4.94, 11.69] 3.0e-20 29

Correlations

Index endpoint: H7_MACULOPATHYDIAB – Diabetic maculopathy
GWS hits: 9

Survival analyses between endpoints

Plot

before Diabetic maculopathy
after Diabetic maculopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic maculopathy