Major coronary heart disease event

DOID EFO MESH PheWeb

intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: only main entry used Yes

Hospital Discharge: ICD-10 I20.0, I21, I22

Hospital discharge: ICD-9 410|4110

Hospital discharge: ICD-8 410|4110

Cause of death: only main entry used Yes

Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98

Cause of death: ICD-9 41[0-4]|798

Cause of death: ICD-8 41[0-4]|798

Cause of death: excluded ICD-9 7980A

Check pre-conditions None

Include endpoints

I9_REVASC

I9_MI

Check conditions None

Apply sex-specific rule None

I9_CHD

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Major coronary heart disease event based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	25662	7667	17995
Unadjusted prevalence (%)	9.87	5.22	15.91
Mean age at first event (years)	64.84	67.87	63.55

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	4.57 [4.13, 5.07]	<1e-100	8812
15 years	0.04	5.66 [5.19, 6.18]	<1e-100	7944
5 years	0.01	11.60 [10.67, 12.62]	<1e-100	4740
1 year	0.01	40.41 [35.21, 46.37]	<1e-100	3123

Correlations

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Index endpoint: I9_CHD – Major coronary heart disease event
GWS hits: 38

Survival analyses between endpoints

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Plot

before Major coronary heart disease event
after Major coronary heart disease event

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Table

Loading survival analyses table

Drugs most likely to be purchased after Major coronary heart disease event

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