Heart failure, not strict

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50

Hospital discharge: ICD-9 4029B|428

Hospital discharge: ICD-8 42700|42710|428|7824

Cause of death: ICD-10 I11.0, I13.0, I13.2, I50

Cause of death: ICD-9 4029B|428

Cause of death: ICD-8 42700|42710|428|7824

KELA reimbursements: KELA codes 201

Medicine purchases: ATC C03CA01|C03EB01

Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

I9_HEARTFAIL_NS

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF6

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List of similar endpoints to Heart failure, not strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

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Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	6.53 [5.92, 7.19]	<1e-100	9591
15 years	0.06	7.24 [6.66, 7.87]	<1e-100	8876
5 years	0.01	9.85 [9.06, 10.71]	<1e-100	4818
1 year	0.00	13.84 [12.04, 15.91]	<1e-100	1485

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Index endpoint: I9_HEARTFAIL_NS – Heart failure, not strict
GWS hits: 3

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before Heart failure, not strict
after Heart failure, not strict

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