Systemic lupus erythematosus

systemic lupus erythematosus: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M32
Hospital discharge: ICD-9 7100
Hospital discharge: ICD-8 7431
Cause of death: ICD-10 M32
Cause of death: ICD-9 7100
Cause of death: ICD-8 7431

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_SLE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30-M36
Name in latin Lupus erythematosus disseminatus (LED)

Summary Statistics

Key figures

All Female Male
Number of individuals 687 575 112
Unadjusted prevalence (%) 0.26 0.39 0.10
Mean age at first event (years) 45.66 44.93 49.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.80 [1.95, 7.40] 8.5e-5 63
15 years 0.03 4.60 [2.50, 8.46] 9.6e-7 51
5 years 0.01 7.61 [3.91, 14.82] 2.4e-9 23
1 year - - - -

Correlations

Index endpoint: M13_SLE – Systemic lupus erythematosus
GWS hits: 3

Survival analyses between endpoints

Plot

before Systemic lupus erythematosus
after Systemic lupus erythematosus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Systemic lupus erythematosus