Spondylopathies

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M45-M49
Cause of death: ICD-10 M45-M49

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_SPONDYLOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 23025 12494 10531
Unadjusted prevalence (%) 8.85 8.50 9.31
Mean age at first event (years) 57.70 57.38 58.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.80 [1.58, 2.05] 6.5e-19 2363
15 years 0.01 2.05 [1.83, 2.29] 7.1e-35 1975
5 years 0.00 2.77 [2.48, 3.11] 2.5e-69 761
1 year 0.00 4.06 [3.37, 4.88] 7.0e-50 210

Correlations

Index endpoint: M13_SPONDYLOPATHY – Spondylopathies
GWS hits: 11

Survival analyses between endpoints

Plot

before Spondylopathies
after Spondylopathies

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