systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
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Check pre-conditions None
Include endpoints None
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Apply sex-specific rule None
M13_SYSTSLCE
Extra metadata
List of similar endpoints to
Systemic sclerosis
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 392 | 320 | 72 |
| Unadjusted prevalence (%) | 0.15 | 0.22 | 0.06 |
| Mean age at first event (years) | 53.53 | 53.54 | 53.53 |
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | 0.12 | 9.25 [5.03, 17.01] | 8.2e-13 | 33 |
| 15 years | 0.06 | 9.46 [4.82, 18.58] | 6.7e-11 | 30 |
| 5 years | 0.02 | 17.35 [9.06, 33.24] | 7.5e-18 | 20 |
| 1 year | - | - | - | - |
Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 0
before Systemic sclerosis
after Systemic sclerosis
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