Systemic sclerosis,strict definition

scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).

Endpoint definition

FinnGen phenotype data
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Filter registries KELA purch., KELA reimb.

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M34

Check pre-conditions None

Include endpoints None

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Check conditions

SYSTSCLE_ICD10

Apply sex-specific rule None

diagram downward connector SYSTSCLE_STRICT

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 134 116 18
Unadjusted prevalence (%) 0.05 0.08 0.02
Mean age at first event (years) 54.18 54.07 54.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits:

Survival analyses between endpoints

Plot

before Systemic sclerosis,strict definition
after Systemic sclerosis,strict definition

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Drugs most likely to be purchased after Systemic sclerosis,strict definition